Re: Prof. Konisky's Posting #poland

bcg <bcg@...>
 

An email was sent to this list earlier today. It was well thought out, and
deserves a prompt answer. I hope that this group will view this response
as both.

1. It is not altogether clear to me that the resolution of the method will
allow definitive
relationships at the level of families.

We use an 11-marker test, of which the Cohanim study is a part. Most
paternity suits use approx. this number and the State of Texas uses less
when checking the physical evidence involved in murder cases. What we are
offering is not brand new, the Hemming's and Jefferson's had their DNA
tested using Y chromosome markers. What they can't tell, and what we can't
tell is whether Thomas Jefferson was the DNA donor or whether it was his
brother, however our tests can show that a Jefferson did donate Y
Chromosomal DNA to the Hemming's family. In this same way we can't say your
Most Recent Common Ancestor (MRCA) was 7 generations ago or 15 generations
ago, however we can say that you and the other matched party are related.


2. It is one thing to be able to link someone to the Cohan group, but quite
another level of resolution is
required to show family relationships among members of this group.

Good comment. We would probably need a 100 marker test to say that one
was related within the last 7 generations at a 99.9% confidence level. Our
numbers are not nearly that accurate (as no 100 marker test is used
anywhere to the best of our knowledge). Please also note that Genetree in
California uses 6 markers and Brian Sykes of Oxford used only 4 markers
when testing for the so called Sykes genealogy which has received
substantial press lately. Our test is far more rigorous then the others.
With every increase in the number of markers, the ability to recognize
relatives within a closer time period becomes a reality. If you want to
know if you and another Kosinsky has a common ancestor, we can answer that
question either Yes or No, and give a projection of when the Most Recent
Common Ancestor (MRCA) lived.

3. What is being promised?

We offer the real possibility of connecting members of the same family that
have an 11/11 match. Please see the Population Geneticist numbers from
Brian Walsh, PhD, a member of our Scientific board, U of Arizona. I will
post a chart and a few graphs on Sunday that will give a pictorial view of
this.

JewishGen will get access to the Surnames Database Library and will be able
to integrate those surnames and the quantity of people who have been tested
in the JGFF. However, Jewishgen will not have access to any of the results
of the tests.

4. Who will own the data?

The data will be housed at the U of Arizona. They make the results of
exact matches available to Family Tree DNA. The same restrictions on data
at Rice should apply to U of A. as far as confidentiality is concerned.

5. Will Family Tree DNA have the right to publish the results of these
studies?

No., however if an individual wants to participate in the growing body of
data used by Prof. Hammer, they can do so by signing the consent form sent
along with each JewishGen order.

6. Will I have the right to remove my genetic profile >from the database at
some later time?

Yes. Just like an email list, if you decide that you want your data
deleted >from the database, you may email us, we will look up you ID number,
and ask that it be deleted >from the Database.

7. If the marker analysis shows that I carry a problematic gene, will I be
informed?

We won't know if you show positive for a disease, as we are only running a
test on the DNA to look for the position of the 11 Loci. We are not doing
tests for BRCA1 or BRCA2. The reason we ask people who volunteer to be in
Prof. Hammer's study if they have a history of Gauchers, Tay Sachs, etc. is
so he can try to identify the geography with the strongest evidence of the
disease, in order to determine where the mutation occurred.

8. How many people must Family Tree DNA analyze in order to make meaningful
connections?

A minimum of 2 excluding the infidelity factor which is estimated at up to
5% per generation, so for families trying 'clan' reconstruction, 2 per
extended family of known relatives would be best.

9. Does JewishGen get any part of the $219 fee.

Yes, JewishGen receives a 14% order-processing fee. The purpose of this is
to help JewishGen maintain and expand its host of services. We hope it
will be very successful.

Best Regards

Bennett Greenspan
President
http://www.FamilyTreeDNA.com
The World's only website dedicated to genealogy by Genetics

Join main@groups.jewishgen.org to automatically receive all group messages.