Re: Inferences from marker comparisons #dna


awestreich@...
 

The approach I have seen to compare markers within a group of (possible)
cousins is to: (1) calculate a "modal haplotype" which approximates the
haplotype of the Most Recent Common Ancestor; and then (2) calculate
each member's genetic distance >from that haplotype. (For a fuller
explanation of this, google "Maurice Gleeson modal haplotype.") I
suspect that the resulting genetic distances will be less than the ones
you have previously calculated.

Allan Westreich

----- Original Message -----
From: "Ralph Baer" <ursusminor@verizon.net>
Date: Wed, 11 May 2016 15:00:02 -0400

For several reasons, I had two of my fourth cousins take Y-chromosome
tests at the 37-marker level. That is, the three of us are great-great-
grandsons of three brothers, Abraham BAER, David BAER, and Lazarus BAER
(me). It turns out that I differ by a genetic distance of 3 and 4 >from
the two them, and they differ by 3 >from each other, which is more than
what would be expected.

On all but one marker where we don't all agree, two of us agree and one
doesn't. E.g., on marker one, our values are 12, 13, and 12. Would it
be a safe bet that the value common between the two us that agree is
also the value which our mutual great-great-great-grandfather, Marx
Nathan BAER had? I would think that even if two us had mutations in the
same marker in the last five generations, it would not be the same
mutation.

The marker where we all differ is #35. The three of us have in
combination with #34 values of 34-35-37, 34-35, and 34-38. Can anything
be said of what the most likely value for our mutual ancestor was?

It would be interesting if I could find a male-line descendant of the
last brother, Kaufmann BAER, of my great-great-grandfather.

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