Descendants of Rabbi Menasseh ben Israel (Manoel de Soeiro) #rabbinic

Michael Sharp
 

I am looking for information on the descendants of Rabbi Menasseh ben Israel. A family story says that a child of a grandson of Menasseh ben Israel was orphaned in a plague outbreak in The Hague and was adopted by some Jewish merchants from Poland. My wife's grandfather claimed descent from the adopted boy. We have not yet been able to verify this. Does anyone have any information on Menasseh ben Israel's grandchildren? It would be his son's children that would be of interest as his daughter's family we believe settled in England. 

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