Thought I would throw another thought into the mix.
My paternal grandmother arrived in the USA in 1921 with 4 children, ages 20, 16, 12 and 9.
My grandfather, her husband, did not arrive until 1924. He was denied passage with the family because of trachoma -- an eye disease. My grandmother and the children came to live with her brother-in-law, my grandfather's brother.
