A search in Pittsburgh city directories for 530 High in the keyword field, and no surname in the search, gets two hits.
1897 - J.W. HOLTZHEIMER, waiter
The only other hit is in 1934.
530 High gets no hits in the timeframe 1900 to 1910.
A search for 530 High Street in the USPS zip code search finds no such address.
The fact that the address gets only 2 hits in the Pittsburgh directories at Ancestry makes me think that the address written on the manifest is a mistake. If it was a valid address it would show up in the many Pittsburgh directories from that timeframe.
I agree with Alan's idea to call the local Pittsburgh public library research librarian for info on the address.
Good luck in your search,
RATOWSKY / CHAIMSON (Ariogala, Lith.); LEFFENFELD / FINK / KALTER (Daliowa & Jasliska, Pol.)
BOJDA / BLEIWEISS (Tarnow & Tarnobrzeg, Pol.); WALTZMAN / WALZMAN (Ustrzyki Dolne, Pol.)
LEVY (Tyrawa Woloska, Pol.); SOLON / SOLAN / SOKOLSKY (Grodek, Bialystok, Pol.)
BOBISH / BLUMENKRANZ / APPEL / WEINER / ROSENBERG (Vysoko-Litovsk, Brest, Biala Podlaska)